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Interleukin 18 receptor 1 gene polymorphisms are associated with asthma

Research output: Contribution to journalArticlepeer-review

  • Guohua Zhu
  • Moira K. B. Whyte
  • Jorgen Vestbo
  • Karin Carlsen
  • Kai-Hakon Carlsen
  • Warren Lenney
  • Michael Silverman
  • Peter Helms
  • Sreekumar G. Pillai

Related Edinburgh Organisations

Original languageEnglish
Pages (from-to)1083-1090
Number of pages8
JournalEuropean Journal of Human Genetics
Volume16
Issue number9
DOIs
Publication statusPublished - Sep 2008

Abstract

The interleukin 18 receptor (IL18R1) gene is a strong candidate gene for sthma. It has been implicated in the pathophysiology of asthma and maps to an asthma susceptibility locus on chromosome 2q12. The possibility of association between polymorphisms in IL18R1 and asthma was examined by genotyping seven SNPs in 294, 342 and 100 families from Denmark, United Kingdom and Norway and conducting family-based association analyses for asthma, atopic asthma and bronchial hyper-reactivity (BHR) phenotypes. Three SNPs in IL18R1 were associated with asthma (0.01131

    Research areas

  • asthma, IL18R1, genetic association, haplotype analysis, replication, GENOME-WIDE SEARCH, SINGLE-NUCLEOTIDE POLYMORPHISMS, NF-KAPPA-B, FOUNDER POPULATION, LINKAGE ANALYSIS, RECEPTOR-ALPHA, IGE LEVELS, SUSCEPTIBILITY, DISEASE, CELLS

ID: 17165791