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Intranasal infection with Chlamydia abortus induces dose-dependent latency and abortion in sheep

Research output: Contribution to journalArticle

  • David Longbottom
  • Morag Livingstone
  • Stephen Maley
  • Arjan van der Zon
  • Mara Rocchi
  • Kim Wilson
  • Nicholas Wheelhouse
  • Mark Dagleish
  • Kevin Aitchison
  • Sean Wattegedera
  • Mintu Nath
  • Gary Entrican
  • David Buxton

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    Rights statement: Copyright: © 2013 Longbottom et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0057950
Original languageEnglish
Article numbere57950
JournalPLoS ONE
Volume8
Issue number2
DOIs
Publication statusPublished - 2013

Abstract

Latency is a key feature of the animal pathogen Chlamydia abortus, where infection remains inapparent in the non-pregnant animal and only becomes evident during a subsequent pregnancy. Often the first sign that an animal is infected is abortion occurring late in gestation. Despite this, little is understood of the underlying mechanisms that control latency or the recrudescence of infection that occurs during subsequent pregnancy. The aim of this study was to develop an experimental model of latency by mimicking the natural route of infection through the intranasal inoculation of non-pregnant sheep with C. abortus.

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