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Investigating Voice as a Biomarker for Leucine-Rich Repeat Kinase 2-Associated Parkinson's Disease

Research output: Contribution to journalArticle

  • Siddharth Arora
  • Naomi P Visanji
  • Tiago A Mestre
  • Athanasios Tsanas
  • Amaal AlDakheel
  • Barbara S Connolly
  • Carmen Gasca-Salas
  • Drew S Kern
  • Jennifer Jain
  • Elizabeth J Slow
  • Achinoam Faust-Socher
  • Anthony E Lang
  • Max A Little
  • Connie Marras

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Original languageEnglish
JournalJournal of Parkinson's disease
Early online date17 Sep 2018
DOIs
Publication statusPublished - 17 Oct 2018

Abstract

We investigate the potential association between leucine-rich repeat kinase 2 (LRRK2) mutations and voice. Sustained phonations ('aaah' sounds) were recorded from 7 individuals with LRRK2-associated Parkinson's disease (PD), 17 participants with idiopathic PD (iPD), 20 non-manifesting LRRK2-mutation carriers, 25 related non-carriers, and 26 controls. In distinguishing LRRK2-associated PD and iPD, the mean sensitivity was 95.4% (SD 17.8%) and mean specificity was 89.6% (SD 26.5%). Voice features for non-manifesting carriers, related non-carriers, and controls were much less discriminatory. Vocal deficits in LRRK2-associated PD may be different than those in iPD. These preliminary results warrant longitudinal analyses and replication in larger cohorts.

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