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Investigation of mutants of Methylophilus methylotrophus which are defective in methanol oxidation

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Original languageEnglish
Pages (from-to)1373-1380
Number of pages8
JournalJournal of General Microbiology
Volume136
Issue number7
DOIs
StatePublished - 1 Jul 1990

Abstract

Five classes of mutants of Methylophilus methylotrophus which are defective in methanol oxidation (Mox-) have been isolated, partially characterized, and complemented using a Sau3A genomic library. Two classes of mutants were defective in production of the α subunit of methanol dehydrogenase, another two classes in the production of both the α subunit and cytochrome c(L), while the fifth class produced the α subunit, but did not contain an active methanol dehydrogenase, nor cytochrome c(L). The genes defective in these mutants were linked.

ID: 75700757