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Involvement of miRNAs in equine follicle development

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)273-282
JournalReproduction
Volume146
Issue number3
Early online date27 Jun 2013
DOIs
Publication statusPublished - 27 Jun 2013

Abstract

Previous evidence from in vitro studies suggests specific roles for a subset of miRNAs, including miR-21, miR-23a, miR-145, miR-503, miR-224, miR-383, miR-378, miR-132 and miR-212, in regulating ovarian follicle development. The objective of this study was to determine changes in the levels of these miRNAs in relation to follicle selection, maturation and ovulation in the monovular equine ovary. In Experiment 1, follicular fluid was aspirated during ovulatory cycles from the dominant (DO) and largest subordinate (S) follicles of an ovulatory wave, and the dominant (DA) follicle of a mid-cycle anovulatory wave (n=6 mares). Follicular fluid levels of progesterone and estradiol were lower (P

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