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Is radiotherapy useful for treating pain in mesothelioma? A phase II trial

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    Rights statement: Copyright © 2015 by the International Association for the Study of Lung Cancer. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives 3.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.

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http://journals.lww.com/jto/Fulltext/2015/06000/Is_Radiotherapy_Useful_for_Treating_Pain_in.12.aspx
Original languageEnglish
Pages (from-to)944-950
JournalJournal of Thoracic Oncology
Volume10
Issue number6
DOIs
Publication statusPublished - Jun 2015

Abstract

INTRODUCTION:: Radiotherapy is often used to treat pain in malignant pleural mesothelioma (MPM) although there is limited evidence to support this. The aim of this trial was to assess the role of radiotherapy for the treatment of pain in MPM.

METHODS:: A multicentre, single arm phase II trial was conducted. Eligible patients fulfilled the following criteria: pathological or radiological diagnosis of MPM; pain secondary to MPM; radiotherapy indicated for pain control; over 18 years of age. Patients had assessments of pain and other symptoms at baseline then received 20Gy in 5 daily fractions. Key follow up points were 5 and 12 weeks post treatment. The primary endpoint measure was assessment of pain at the site of radiotherapy at 5 weeks. Secondary endpoints included effects on quality of life, breathlessness, fatigue, mood, toxicity and the radiological response.

RESULTS:: Forty patients were recruited from three UK oncology centres. Fourteen patients had a clinically meaningful improvement in their pain 5 weeks post radiotherapy (intention to treat), with 5 patients having a complete improvement. Based on a complete case analysis of the 30 patients assessable at week 5, 47% (CI 28.3-65.7) of patients alive at week 5 had an improvement in their pain. There was no improvement in other key symptoms or quality of life.

CONCLUSIONS:: Radiotherapy for pain control in MPM is an effective treatment in a proportion of patients. Future studies examining differing radiotherapy regimens with a view to improving response rates are warranted.

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