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Kinetic modelling as a modern technology to explore and modify living cells

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Original languageEnglish
Title of host publicationModelling in Molecular Biology
PublisherSpringer Berlin Heidelberg
Pages59-103
Number of pages45
ISBN (Electronic)978-3-642-18734-6
ISBN (Print)978-3-642-62269-4
DOIs
Publication statusPublished - 2004

Publication series

NameNatural Computing Series
PublisherSpringer Berlin Heidelberg
ISSN (Print)1619-7127

Abstract

We describe a general strategy that enables us to develop kinetic models of large-scale metabolic systems by collecting and using all available metabolic experimental data. Our approach can be used to explore the local and global regulatory properties of selected metabolic pathways, and to predict how cell genome modifications can meet selected biotechnological and biomedical criteria. We have applied the strategy for the development and use of detailed kinetic models of catabolic and anabolic pathways of E. coli and mitochondrial energy metabolism.

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