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kruX: Matrix-based non-parametric eQTL discovery

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  • Jianlong Qi
  • Hassan Foroughi Asl
  • Johan Bjorkegren
  • Tom Michoel

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    Rights statement: © 2014 Qi et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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http://www.biomedcentral.com/1471-2105/15/11
Original languageEnglish
Article number11
JournalBMC Bioinformatics
Volume15
Issue number1
DOIs
Publication statusPublished - 14 Jan 2014

Abstract

The Kruskal-Wallis test is a popular non-parametric statistical test for identifying expression quantitativetrait loci (eQTLs) from genome-wide data due to its robustness against variations in the underlyinggenetic model and expression trait distribution, but testing billions of marker-trait combinationsone-by-one can become computationally prohibitive.

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