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LINking microRNAs, kidney development, and Wilms tumors

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    Rights statement: © 2014 Hohenstein and Hastie; Published by Cold Spring Harbor Laboratory Press This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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http://genesdev.cshlp.org/content/28/9/923
Original languageEnglish
Pages (from-to)923-5
Number of pages3
JournalGenes & Development
Volume28
Issue number9
DOIs
Publication statusPublished - 1 May 2014

Abstract

In this issue of Genes & Development, Urbach and colleagues (pp. 971-982) provide compelling data suggesting a role for LIN28 in the pathogenesis of a significant percentage of Wilms tumors. These data extend our insights in the genetics underlying Wilms tumor development and emphasize the importance of stemness and microRNA-mediated processes in the origins of these tumors.

    Research areas

  • Lin28, Wilms Tumor, KIDNEY DEVELOPMENT

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