Edinburgh Research Explorer

Locomotor recovery following contusive spinal cord injury does not require oligodendrocyte remyelination

Research output: Contribution to journalArticle

  • Greg J Duncan
  • Sohrab B Manesh
  • Brett J Hilton
  • Peggy Assinck
  • Jie Liu
  • Aaron Moulson
  • Jason R Plemel
  • Wolfram Tetzlaff

Related Edinburgh Organisations

Open Access permissions



  • Download as Adobe PDF

    Rights statement: Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

    Final published version, 11.3 MB, PDF document

    Licence: Creative Commons: Attribution (CC-BY)

Original languageEnglish
Pages (from-to)3066
JournalNature Communications
Issue number1
Publication statusPublished - 3 Aug 2018


Remyelination occurs after spinal cord injury (SCI) but its functional relevance is unclear. We assessed the necessity of myelin regulatory factor (Myrf) in remyelination after contusive SCI by deleting the gene from platelet-derived growth factor receptor alpha positive (PDGFRα-positive) oligodendrocyte progenitor cells (OPCs) in mice prior to SCI. While OPC proliferation and density are not altered by Myrf inducible knockout after SCI, the accumulation of new oligodendrocytes is largely prevented. This greatly inhibits myelin regeneration, resulting in a 44% reduction in myelinated axons at the lesion epicenter. However, spontaneous locomotor recovery after SCI is not altered by remyelination failure. In controls with functional MYRF, locomotor recovery precedes the onset of most oligodendrocyte myelin regeneration. Collectively, these data demonstrate that MYRF expression in PDGFRα-positive cell derived oligodendrocytes is indispensable for myelin regeneration following contusive SCI but that oligodendrocyte remyelination is not required for spontaneous recovery of stepping.

    Research areas

  • Animals, Axons/metabolism, Behavior, Animal, Cell Differentiation, Cell Proliferation, Disease Models, Animal, Female, Gene Deletion, Male, Mice, Mice, Knockout, Myelin Sheath/metabolism, Nerve Regeneration/physiology, Neural Stem Cells/pathology, Oligodendroglia/metabolism, Receptor, Platelet-Derived Growth Factor alpha, Remyelination/physiology, Spinal Cord/metabolism, Spinal Cord Injuries/metabolism, Transcription Factors/genetics

Download statistics

No data available

ID: 133869526