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Lymphoid hyperplasia and lymphoma in transgenic mice expressing the small non-coding RNA, EBER1 of Epstein-Barr virus

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http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0009092
Original languageEnglish
Article numbere9092
JournalPLoS ONE
Volume5
Issue number2
DOIs
StatePublished - 2010

Abstract

Non-coding RNAs have critical functions in diverse biological processes, particularly in gene regulation. Viruses, like their host cells, employ such functional RNAs and the human cancer associated Epstein-Barr virus (EBV) is no exception. Nearly all EBV associated tumours express the EBV small, non-coding RNAs (EBERs) 1 and 2, however their role in viral pathogenesis remains largely obscure.

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