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Macrophage biology in development, homeostasis and disease

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    Rights statement: Published in final edited form as: Nature. Apr 25, 2013; 496(7446): 445–455.

    Accepted author manuscript, 2.24 MB, PDF document

http://www.nature.com/nature/journal/v496/n7446/full/nature12034.html#affil-auth
Original languageEnglish
Pages (from-to)445-55
Number of pages11
JournalNature
Volume496
Issue number7446
DOIs
Publication statusPublished - 25 Apr 2013

Abstract

Macrophages, the most plastic cells of the haematopoietic system, are found in all tissues and show great functional diversity. They have roles in development, homeostasis, tissue repair and immunity. Although tissue macrophages are anatomically distinct from one another, and have different transcriptional profiles and functional capabilities, they are all required for the maintenance of homeostasis. However, these reparative and homeostatic functions can be subverted by chronic insults, resulting in a causal association of macrophages with disease states. In this Review, we discuss how macrophages regulate normal physiology and development, and provide several examples of their pathophysiological roles in disease. We define the 'hallmarks' of macrophages according to the states that they adopt during the performance of their various roles, taking into account new insights into the diversity of their lineages, identities and regulation. It is essential to understand this diversity because macrophages have emerged as important therapeutic targets in many human diseases.

    Research areas

  • Animals, Cell Lineage, Disease, Fibrosis, Growth and Development, Homeostasis, Humans, Macrophages

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