Edinburgh Research Explorer

Mature oligodendrocytes bordering lesions limit demyelination and favor myelin repair via heparan sulfate production

Research output: Contribution to journalArticlepeer-review

  • Magali Macchi
  • Karine Magalon
  • Céline Zimmer
  • Elitsa Peeva
  • Bilal El Waly
  • Béatrice Brousse
  • Sarah Jaekel
  • Kay Grobe
  • Friedemann Kiefer
  • Anna Williams
  • Myriam Cayre
  • Pascale Durbec

Related Edinburgh Organisations

Open Access permissions



  • Download as Adobe PDF

    Accepted author manuscript, 26.5 MB, PDF document

    Licence: Creative Commons: Attribution (CC-BY)

Original languageEnglish
Publication statusPublished - 9 Jun 2020


Myelin destruction is followed by resident glia activation and mobilization of endogenous progenitors (OPC) which participate in myelin repair. Here we show that in response to demyelination, mature oligodendrocytes (OLG) bordering the lesion express Ndst1, a key enzyme for heparan sulfates (HS) synthesis. Ndst1+ OLG form a belt that demarcates lesioned from intact white matter. Mice with selective inactivation of Ndst1 in the OLG lineage display increased lesion size, sustained microglia and OPC reactivity. HS production around the lesion allows Sonic hedgehog (Shh) binding and favors the local enrichment of this morphogen involved in myelin regeneration. In MS patients, Ndst1 is also found overexpressed in oligodendroglia and the number of Ndst1-expressing oligodendroglia is inversely correlated with lesion size and positively correlated with remyelination potential. Our study suggests that mature OLG surrounding demyelinated lesions are not passive witnesses but contribute to protection and regeneration by producing HS.

Download statistics

No data available

ID: 179451453