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Measurement of regional brain temperature using proton spectroscopic imaging: validation and application to acute ischemic stroke

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)699-706
Number of pages8
JournalMagnetic Resonance Imaging
Issue number6
Publication statusPublished - Jul 2006


A magnetic resonance proton spectroscopic imaging (SI) technique was developed to measure regional brain temperatures in human subjects. The technique was validated in a homogeneous phantom and in four healthy volunteers. Simulations and calculations determined the theoretical measurement precision as approximately +/-0.3 degrees C for individual 1-ml voxels. In healthy volunteers, repeated measurements on individual voxels had an S.D. = 1.2 degrees C. In a clinical study, 40 patients with acute ischemic stroke were imaged within 26 h (mean, 10 h) of onset. Temperatures were highest in the region that appeared abnormal (i.e., ischemic) on diffusion-weighted imaging (DWI) compared with a normal-appearing brain. The mean temperature difference between the DWI "lesion" area and the "normal brain" was 0.17 degrees C [P < 10(-3); range, 2.45 degrees C (hotter)-2.17 degrees C (cooler)]. Noninvasive temperature measurement by SI has sufficient precision to be used in studies of pathophysiology in stroke and in other brain disorders and to monitor therapies.

    Research areas

  • Aged, Aged, 80 and over, Body Temperature, Brain, Brain Ischemia, Diffusion Magnetic Resonance Imaging, Female, Humans, Magnetic Resonance Spectroscopy, Male, Middle Aged, Phantoms, Imaging, Stroke

ID: 17842471