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Mechanism and regulation of the nonsense-mediated decay pathway

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    Rights statement: © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Original languageEnglish
Pages (from-to)1483-1495
Number of pages13
JournalNucleic Acids Research
Publication statusPublished - 14 Jan 2016


The Nonsense-mediated mRNA decay (NMD) pathway
selectively degrades mRNAs harboring premature
termination codons (PTCs) but also regulates
the abundance of a large number of cellular RNAs.
The central role of NMD in the control of gene expression
requires the existence of buffering mechanisms
that tightly regulate the magnitude of this pathway.
Here, we will focus on the mechanism of NMD with
an emphasis on the role of RNA helicases in the transition
from NMD complexes that recognize a PTC to
those that promote mRNA decay. We will also review
recent strategies aimed at uncovering novel transacting
factors and their functional role in the NMD
pathway. Finally, we will describe recent progress in
the study

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