Meta-analysis of pre-clinical studies of early decompression in acute spinal cord injury: a battle of time and pressure

Peter E Batchelor; Taryn E Wills; Peta Skeers; Camila R Battistuzzo; Malcolm R Macleod; David W Howells; Emily S Sena

doi:10.1371/journal.pone.0072659

Meta-analysis of pre-clinical studies of early decompression in acute spinal cord injury: a battle of time and pressure

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Peter E Batchelor
Taryn E Wills
Peta Skeers
Camila R Battistuzzo
Malcolm R Macleod
David W Howells
Emily S Sena

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Rights statement: Copyright: © 2013 Batchelor et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0072659

Original language	English
Pages (from-to)	e72659
Journal	PLoS ONE
Volume	8
Issue number	8
DOIs	https://doi.org/10.1371/journal.pone.0072659
Publication status	Published - 2013

Abstract

The use of early decompression in the management of acute spinal cord injury (SCI) remains contentious despite many pre-clinical studies demonstrating benefits and a small number of supportive clinical studies. Although the pre-clinical literature favours the concept of early decompression, translation is hindered by uncertainties regarding overall treatment efficacy and timing of decompression.

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