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Methods for Precisely Localised Transfer of Cells or DNA into Early Postimplantation Mouse Embryos

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Original languageEnglish
Article numbere53295
JournalJournal of Visualized Experiments (JoVE)
Issue number106
Publication statusPublished - 25 Dec 2015


We demonstrate a method for grafting cultured cells into defined sites of early mouse embryos to determine their in vivo potential. We also introduce an optimized electroporation method that uses glass capillaries of known diameter, allowing the precise delivery of exogenous DNA into a few cells in the embryos.

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