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Microarray gene expression profiling of neural tissues in bovine spastic paresis

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  • Lorraine Pariset
  • Silvia Bongiorni
  • Susana Bueno
  • Cesare E M Gruber
  • Gianluca Prosperini
  • Giovanni Chillemi
  • Silvia Bicorgna
  • Arcangelo Gentile
  • Alessio Valentini

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Original languageEnglish
Article number122
JournalBMC Veterinary Research
Volume9
DOIs
Publication statusPublished - 2013

Abstract

Bovine Spastic Paresis (BSP) is a neuromuscular disorder which affects both male and female cattle. BSP is characterized by spastic contraction and overextension of the gastrocnemious muscle of one or both limbs and is associated with a scarce increase in body weight. This disease seems to be caused by an autosomal and recessive gene, with incomplete penetration, although no genes clearly involved with its onset have been so far identified. We employed cDNA microarrays to identify metabolic pathways affected by BSP in Romagnola cattle breed. Investigation of those pathways at the genome level can help to understand this disease.

    Research areas

  • Animals, Cattle, Cattle Diseases, Female, Gene Expression, Gene Expression Profiling, Male, Nervous System, Oligonucleotide Array Sequence Analysis, Paraparesis, Spastic, Real-Time Polymerase Chain Reaction, Sarcoplasmic Reticulum Calcium-Transporting ATPases

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