Edinburgh Research Explorer

Microarray resources for genetic and genomic studies in chicken: a review

Research output: Contribution to journalArticle

Related Edinburgh Organisations

Open Access permissions

Open

Documents

  • Download as Adobe PDF

    Rights statement: Available under Open Access

    Final published version, 167 KB, PDF-document

http://onlinelibrary.wiley.com/doi/10.1002/dvg.22387/abstract;jsessionid=F8FADDA162E6C7723B8F35E2386C8968.d03t02
Original languageEnglish
Pages (from-to)337-356
JournalGenesis
Volume51
Issue number5 (Sp Iss S1)
Early online date26 Mar 2013
DOIs
StatePublished - Mar 2013

Abstract

Advent of microarray technologies revolutionized the nature and scope of genetic and genomic research in human and other species by allowing massively parallel analysis of thousands of genomic sites. They have been used for diverse purposes such as for transcriptome analysis, CNV detection, SNP and CNV genotyping, studying DNA-protein interaction, and detection of genome methylation. Microarrays have also made invaluable contributions to research in chicken which is an important model organism for studying embryology, immunology, oncology, virology, evolution, genetics, and genomics and also for other avian species. Despite their huge contributions in life science research, the future of microarrays is now being questioned with the advent of massively parallel next generation sequencing (NGS) technologies, which promise to overcome some of the limitations of microarray platforms. In this article we review the various microarray resources developed for chicken and their past and potential future applications. We also discuss about the future of microarrays in the NGS era particularly in the context of livestock genetics. We argue that even though NGS promises some major advantages-in particular, offers the opportunity to discover novel elements in the genome-microarrays will continue to be major tools for research and practice in the field of livestock genetics/genomics due to their affordability, high throughput nature, mature established technologies and ease of application. Moreover, with advent of new microarray technologies like capture arrays, the NGS and microarrays are expected to complement each other in future research in life science. genesis 00:1-20. © 2013 Wiley Periodicals, Inc.

Download statistics

No data available

ID: 7540732