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Microglia in developing white matter and perinatal brain injury

Research output: Contribution to journalReview article

Original languageEnglish
Pages (from-to)134539
JournalNeuroscience Letters
Early online date12 Oct 2019
DOIs
Publication statusE-pub ahead of print - 12 Oct 2019

Abstract

Perinatal brain injury (PBI) to the developing white matter results in hypomyelination of axons and can cause long-term motor and cognitive deficits e.g. cerebral palsy. There are currently no approved therapies aimed at repairing the white matter following insult, underscoring the need to investigate the mechanisms underlying the pathogenesis of PBI. Microglia have been strongly implicated, but their function and heterogeneity in this context remain poorly understood, posing a barrier to the development of microglia-targeted therapies for white matter repair following PBI. In this review, we discuss the roles of microglia in normal white matter development and in PBI, and potential drug strategies to influence microglial responses in this setting.

ID: 120284850