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Microwave-assisted coupling with DIC/HOBt for the synthesis of difficult peptoids and fluorescently labelled peptides - a gentle heat goes a long way

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Original languageEnglish
Pages (from-to)1011-1014
Number of pages4
JournalTetrahedron Letters
Volume47
Issue number6
DOIs
Publication statusPublished - 6 Feb 2006

Abstract

Mild thermal effects (Arrhenius based) achieved with microwave heating proved to be highly successful in enabling rapid and efficient secondary amine couplings and the labelling of peptides with a variety of fluorophores and quenchers in high yields and purities with just traditional, yet robust, HOBt/DIC chemistry. (c) 2005 Elsevier Ltd. All rights reserved.

    Research areas

  • IRRADIATION, FMOC, DDE

ID: 1513866