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Model Selection Approach Suggests Causal Association between 25-Hydroxyvitamin D and Colorectal Cancer

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    Rights statement: Copyright: © 2013 Zgaga et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0063475
Original languageEnglish
Article numbere63475
Number of pages11
JournalPLoS ONE
Volume8
Issue number5
DOIs
Publication statusPublished - 24 May 2013

Abstract

Vitamin D deficiency has been associated with increased risk of colorectal cancer (CRC), but causal relationship has not yet been confirmed. We investigate the direction of causation between vitamin D and CRC by extending the conventional approaches to allow pleiotropic relationships and by explicitly modelling unmeasured confounders.

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