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Modulation of host immunity by helminths : the expanding repertoire of parasite effector molecules

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Original languageEnglish
Pages (from-to)801-818
JournalImmunity
Volume49
Issue number5
Early online date30 Nov 2018
DOIs
Publication statusE-pub ahead of print - 30 Nov 2018

Abstract

Helminths are extraordinarily successful parasites due to their ability to modulate the host immune response. They have evolved a spectrum of immunomodulatory molecules which are now beginning to be defined, heralding a molecular revolution in parasite immunology. These discoveries have the potential both to revolutionise our understanding of parasite adaptation to the host, and to develop possible therapies for immune-mediated disease. In this review we will summarise the current state of the art in parasite immunomodulation and discuss perspectives on future areas for research and discovery.

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