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Mycobacterium bovis infections in slaughter pigs in Mubende district, Uganda: a public health concern

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  • Adrian Muwonge
  • Tone B Johansen
  • Edvardsen Vigdis
  • Jacques Godfroid
  • Francisco Olea-Popelka
  • Demelash Biffa
  • Eystein Skjerve
  • Berit Djønne

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    Rights statement: © 2012 Muwonge et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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http://www.biomedcentral.com/1746-6148/8/168
Original languageEnglish
Pages (from-to)168
JournalBMC Veterinary Research
Volume8
DOIs
Publication statusPublished - 2012

Abstract

Bovine tuberculosis (TB) caused by Mycobacterium bovis is primarily a disease of ruminants, particularly cattle (Bos primigenius) and buffalo (Syncerus caffer), and is endemic in most developing countries. To date, studies done in Uganda have documented the prevalence of M. bovis in cattle, humans and wild life, in addition to non-tuberculous mycobacteria in pigs. Pigs are increasingly becoming an important component of the livestock sector and share the human ecosystem in rural Uganda. It is therefore of public health interest that they are not a source of human infections. As a follow up to previously published findings on mycobacteria in pigs, this study was aimed at investigating the occurrence and molecular characteristics of M. bovis detected in slaughter pigs in Mubende district, Uganda. One hundred fifty mesenteric lymph nodes with lesions suggestive of mycobacterial infections were collected from approximately one thousand slaughtered pigs in Mubende district over a period of five months. The isolation and identification of M. bovis was done using conventional mycobacteriological methods. Mycobacteria belonging to the Mycobacterium tuberculosis complex (MTC) were identified to species level using deletion analysis. Molecular typing was done using Spoligotyping and MIRU-VNTR analysis. Molecular data were analysed and interpreted using MIRU-VNTR plus, SpolDB4.0 and the Mycobacterium bovis spoligo database.

    Research areas

  • Swine, Animals, Abattoirs, Humans, Uganda, Tuberculosis, Swine Diseases, Mycobacterium bovis, Lymph Nodes, Male, Female

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