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Myxomatous Degeneration of the Canine Mitral Valve: From Gross Changes to Molecular Events

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Original languageEnglish
Pages (from-to)371-383
JournalJournal of Comparative Pathology
Issue number4
Early online date10 Apr 2017
Publication statusPublished - May 2017


Myxomatous mitral valve disease (MMVD) is the single most common acquired heart
disease of the dog, but is also of emerging importance in human medicine, with some features of the disease shared between both species. There has been increased understanding of this disease in recent years, with most research aiming to elucidate the cellular and molecular events of disease pathogenesis. For gross and histological changes, much of our understanding is based on historical studies and there has been no comprehensive re-appraisal of the pathology of MMVD. This paper reviews the gross, histological, ultrastructural, cellular and molecular changes in canine MMVD.

    Research areas

  • myxomatous mitral valve disease, dog, pathology, gene expression

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