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Natural product-inspired profluorophores for imaging NQO1 activity in tumour tissues

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Original languageEnglish
JournalBioorganic and Medicinal Chemistry
Early online date15 Jul 2019
Publication statusE-pub ahead of print - 15 Jul 2019


Herein we designed a collection of trimethyl-lock quinone profluorophores as activity-based probes for imaging NAD(P)H:quinone oxidoreductase (NQO1) in cancer cells and tumour tissues. Profluorophores were prepared via synthetic routes from naturally-occurring quinones and characterised in vitro using recombinant enzymes, to be further validated in cells and fresh frozen canine tumour tissues as potential new tools for cancer detection and imaging.

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