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NDE1 and NDEL1: Multimerisation, alternate splicing and DISC1 interaction

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)228-233
Number of pages6
JournalNeuroscience Letters
Volume449
Issue number3
DOIs
Publication statusPublished - Jan 2009

Abstract

Nuclear Distribution Factor E Homolog 1 (NDE1) and NDE-Like 1 (NDEL1) are highly homologous mammalian proteins. However, whereas NDEL1 is well studied, there is remarkably little known about NDE1. We demonstrate the presence of multiple isoforms of both NDE1 and NDEL1 in the brain, showing that NDE1 binds directly to multiple isoforms of Disrupted in Schizophrenia 1 (DISC1), and to itself We also show that NDE1 can complex with NDEL1. Together these results predict a high degree of complexity of DISC1-mediated regulation of neuronal activity. (c) 2008 Elsevier Ireland Ltd. All rights reserved.

    Research areas

  • DISC1, LIS1, NDE1, NDEL1, Schizophrenia

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