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Neutrophil apoptosis in infectious disease

Research output: Contribution to journalLiterature reviewpeer-review

Original languageEnglish
Pages (from-to)519-528
Number of pages10
JournalExperimental Lung Research
Volume33
Issue number10
DOIs
Publication statusPublished - Dec 2007
Event25th Meeting of the British-Association-for-Lung-Research - Sheffield, United Kingdom
Duration: 1 Jul 2006 → …

Abstract

Apoptosis, or programmed cell death, is a highly conserved cellular suicide mechanism. Apoptosis is critical to the effective resolution of inflammation, particularly in regulating the lifespan of the inflammatory neutrophil. Pathological dysregulation of neutrophil apoptosis prevents resolution of inflammation and is implicated in numerous inflammatory conditions. Similarly, subversion of this critical, host defense mechanism by pathogens can prevent resolution of infection. Below, we describe the effects of different bacterial pathogens on regulation of neutrophil apoptosis and consider how re-engagement of these subverted mechanisms may facilitate the develophtent of new strategies to combat infectious diseases.

    Research areas

  • apoptosis, bacteria, infection, neutrophil, pathogens, PANTON-VALENTINE LEUKOCIDIN, HUMAN POLYMORPHONUCLEAR LEUKOCYTES, COLONY-STIMULATING FACTOR, PROGRAMMED CELL-DEATH, STAPHYLOCOCCUS-AUREUS, IN-VIVO, ESCHERICHIA-COLI, DIFFERENTIATION PROGRAM, NECROTIZING PNEUMONIA, NEISSERIA-GONORRHOEAE

Event

25th Meeting of the British-Association-for-Lung-Research

1/07/06 → …

United Kingdom

Event: Conference

ID: 17166347