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Non-growing follicle density is increased following adriamycin, bleomycin, vinblastine and dacarbazine (ABVD) chemotherapy in the adult human ovary

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Original languageEnglish
JournalHuman Reproduction
Early online date5 Dec 2016
DOIs
Publication statusE-pub ahead of print - 5 Dec 2016

Abstract

Study question: Do the chemotherapeutic regimens of ABVD (adriamycin, bleomycin, vinblastine and dacarbazine), or OEPA-COPDAC (combined vincristine, etoposide, prednisone, doxorubicin (OEPA) and cyclophosphamide, vincristine, prednisone, dacarbazine (COPDAC)) used to treat Hodgkin lymphoma, affect the density, morphology and in vitro developmental potential of human ovarian follicles?

Summary answer: Ovarian tissue from women treated with ABVD contained a higher density of non-growing follicles/mm3 and increased numbers of multi-ovular follicles, but showed reduced in vitro growth compared with patients with lymphoma who had not received chemotherapy, patients treated with OEPA-COPDAC, age-matched healthy women and age-related model-predicted values.

    Research areas

  • OVARY, follicle, lymphoma, ABVD, oocyte

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