Edinburgh Research Explorer

Novel genetic loci associated with hippocampal volume

Research output: Contribution to journalArticle

  • Derrek P. Hibar
  • Hieab H. H. Adams
  • Neda Jahanshad
  • Ganesh Chauhan
  • Jason L. Stein
  • Edith Hofer
  • Miguel E. Renteria
  • Joshua C. Bis
  • Alejandro Arias-vasquez
  • M. Kamran Ikram
  • Sylvane Desrivières
  • Meike W. Vernooij
  • Lucija Abramovic
  • Saud Alhusaini
  • Najaf Amin
  • Micael Andersson
  • Konstantinos Arfanakis
  • Nicola J. Armstrong
  • Lavinia Athanasiu
  • Tomas Axelsson
  • Ashley H. Beecham
  • Alexa Beiser
  • Manon Bernard
  • Susan H. Blanton
  • Marc M. Bohlken
  • Marco P. Boks
  • Janita Bralten
  • Adam M. Brickman
  • Owen Carmichael
  • M. Mallar Chakravarty
  • Qiang Chen
  • Christopher R. K. Ching
  • Vincent Chouraki
  • Gabriel Cuellar-partida
  • Fabrice Crivello
  • Anouk Den Braber
  • Nhat Trung Doan
  • Stefan Ehrlich
  • Sudheer Giddaluru
  • Aaron L. Goldman
  • Rebecca F. Gottesman
  • Oliver Grimm
  • Michael E. Griswold
  • Tulio Guadalupe
  • Boris A. Gutman
  • Johanna Hass
  • Unn K. Haukvik
  • David Hoehn
  • Avram J. Holmes
  • Martine Hoogman
  • Deborah Janowitz
  • Tianye Jia
  • Kjetil N. Jørgensen
  • Nazanin Karbalai
  • Dalia Kasperaviciute
  • Sungeun Kim
  • Marieke Klein
  • Bernd Kraemer
  • Phil H. Lee
  • David C. M. Liewald
  • Lorna M. Lopez
  • Christine Macare
  • Andre F. Marquand
  • Mar Matarin
  • Karen A. Mather
  • Manuel Mattheisen
  • David R. Mckay
  • Yuri Milaneschi
  • Kwangsik Nho
  • Allison C. Nugent
  • Paul Nyquist
  • Loes M. Olde Loohuis
  • Jaap Oosterlaan
  • Martina Papmeyer
  • Lukas Pirpamer
  • Benno Pütz
  • Adaikalavan Ramasamy
  • Jennifer S. Richards
  • Shannon L. Risacher
  • Roberto Roiz-santiañez
  • Nanda Rommelse
  • Stefan Ropele
  • Emma J. Rose
  • Tatjana Rundek
  • Philipp G. Sämann
  • Arvin Saremi
  • Claudia L. Satizabal
  • Lianne Schmaal
  • Andrew J. Schork
  • Li Shen
  • Jean Shin
  • Elena Shumskaya
  • Albert V. Smith
  • Emma Sprooten
  • Lachlan T. Strike
  • Alexander Teumer
  • Diana Tordesillas-gutierrez
  • Roberto Toro
  • Daniah Trabzuni
  • Stella Trompet
  • Dhananjay Vaidya
  • Jeroen Van Der Grond
  • Sven J. Van Der Lee
  • Dennis Van Der Meer
  • Marjolein M. J. Van Donkelaar
  • Kristel R. Van Eijk
  • Theo G. M. Van Erp
  • Daan Van Rooij
  • Esther Walton
  • Lars T. Westlye
  • Christopher D. Whelan
  • Beverly G. Windham
  • Anderson M. Winkler
  • Katharina Wittfeld
  • Girma Woldehawariat
  • Christiane Wolf
  • Thomas Wolfers
  • Lisa R. Yanek
  • Jingyun Yang
  • Alex Zijdenbos
  • Marcel P. Zwiers
  • Ingrid Agartz
  • Laura Almasy
  • David Ames
  • Philippe Amouyel
  • Ole A. Andreassen
  • Sampath Arepalli
  • Amelia A. Assareh
  • Sandra Barral
  • Diane M. Becker
  • James T. Becker
  • David A. Bennett
  • John Blangero
  • Hans Van Bokhoven
  • Dorret I. Boomsma
  • Henry Brodaty
  • Rachel M. Brouwer
  • Han G. Brunner
  • Randy L. Buckner
  • Jan K. Buitelaar
  • Kazima B. Bulayeva
  • Wiepke Cahn
  • Vince D. Calhoun
  • Dara M. Cannon
  • Gianpiero L. Cavalleri
  • Ching-yu Cheng
  • Sven Cichon
  • Mark R. Cookson
  • Aiden Corvin
  • Benedicto Crespo-facorro
  • Joanne E. Curran
  • Michael Czisch
  • Anders M. Dale
  • Gareth E. Davies
  • Anton J. M. De Craen
  • Eco J. C. De Geus
  • Philip L. De Jager
  • Greig I. De Zubicaray
  • Stéphanie Debette
  • Charles Decarli
  • Norman Delanty
  • Chantal Depondt
  • Anita Destefano
  • Allissa Dillman
  • Srdjan Djurovic
  • Gary Donohoe
  • Wayne C. Drevets
  • Ravi Duggirala
  • Thomas D. Dyer
  • Christian Enzinger
  • Susanne Erk
  • Thomas Espeseth
  • Iryna O. Fedko
  • Guillén Fernández
  • Luigi Ferrucci
  • Simon E. Fisher
  • Debra A. Fleischman
  • Ian Ford
  • Myriam Fornage
  • Tatiana M. Foroud
  • Peter T. Fox
  • Clyde Francks
  • Masaki Fukunaga
  • J. Raphael Gibbs
  • David C. Glahn
  • Randy L. Gollub
  • Harald H. H. Göring
  • Robert C. Green
  • Oliver Gruber
  • Vilmundur Gudnason
  • Sebastian Guelfi
  • Asta K. Håberg
  • Narelle K. Hansell
  • John Hardy
  • Catharina A. Hartman
  • Ryota Hashimoto
  • Katrin Hegenscheid
  • Andreas Heinz
  • Stephanie Le Hellard
  • Dena G. Hernandez
  • Dirk J. Heslenfeld
  • Beng-choon Ho
  • Pieter J. Hoekstra
  • Wolfgang Hoffmann
  • Albert Hofman
  • Florian Holsboer
  • Georg Homuth
  • Norbert Hosten
  • Jouke-jan Hottenga
  • Matthew Huentelman
  • Hilleke E. Hulshoff Pol
  • Masashi Ikeda
  • Clifford R. Jack Jr
  • Mark Jenkinson
  • Robert Johnson
  • Erik G. Jönsson
  • J. Wouter Jukema
  • René S. Kahn
  • Ryota Kanai
  • Iwona Kloszewska
  • David S. Knopman
  • Peter Kochunov
  • John B. Kwok
  • Hervé Lemaître
  • Xinmin Liu
  • Dan L. Longo
  • Oscar L. Lopez
  • Simon Lovestone
  • Oliver Martinez
  • Jean-luc Martinot
  • Venkata S. Mattay
  • Colm Mcdonald
  • Francis J. Mcmahon
  • Katie L. Mcmahon
  • Patrizia Mecocci
  • Ingrid Melle
  • Andreas Meyer-lindenberg
  • Sebastian Mohnke
  • Grant W. Montgomery
  • Derek W. Morris
  • Thomas H. Mosley
  • Thomas W. Mühleisen
  • Bertram Müller-myhsok
  • Michael A. Nalls
  • Matthias Nauck
  • Thomas E. Nichols
  • Wiro J. Niessen
  • Markus M. Nöthen
  • Lars Nyberg
  • Kazutaka Ohi
  • Rene L. Olvera
  • Roel A. Ophoff
  • Massimo Pandolfo
  • Tomas Paus
  • Zdenka Pausova
  • Brenda W. J. H. Penninx
  • G. Bruce Pike
  • Steven G. Potkin
  • Bruce M. Psaty
  • Simone Reppermund
  • Marcella Rietschel
  • Joshua L. Roffman
  • Nina Romanczuk-seiferth
  • Jerome I. Rotter
  • Mina Ryten
  • Ralph L. Sacco
  • Perminder S. Sachdev
  • Andrew J. Saykin
  • Reinhold Schmidt
  • Helena Schmidt
  • Peter R. Schofield
  • Sigurdur Sigursson
  • Andrew Simmons
  • Andrew Singleton
  • Sanjay M. Sisodiya
  • Colin Smith
  • Jordan W. Smoller
  • Hilkka Soininen
  • Vidar M. Steen
  • David J. Stott
  • Jessika E. Sussmann
  • Anbupalam Thalamuthu
  • Arthur W. Toga
  • Bryan J. Traynor
  • Juan Troncoso
  • Magda Tsolaki
  • Christophe Tzourio
  • Andre G. Uitterlinden
  • Marcel Van Der Brug
  • Aad Van Der Lugt
  • Nic J. A. Van Der Wee
  • Neeltje E. M. Van Haren
  • Dennis Van ’t Ent
  • Marie-jose Van Tol
  • Badri N. Vardarajan
  • Bruno Vellas
  • Dick J. Veltman
  • Henry Völzke
  • Henrik Walter
  • Thomas H. Wassink
  • Michael E. Weale
  • Daniel R. Weinberger
  • Michael W. Weiner
  • Wei Wen
  • Eric Westman
  • Tonya White
  • Tien Y. Wong
  • Clinton B. Wright
  • Ronald H. Zielke
  • Alan B. Zonderman
  • Nicholas G. Martin
  • Cornelia M. Van Duijn
  • Margaret J. Wright
  • W. T. Longstreth
  • Gunter Schumann
  • Hans J. Grabe
  • Barbara Franke
  • Lenore J. Launer
  • Sarah E. Medland
  • Sudha Seshadri
  • Paul M. Thompson
  • M. Arfan Ikram

Related Edinburgh Organisations

Open Access permissions

Open

Documents

  • Download as Adobe PDF

    Final published version, 1 MB, PDF-document

    Licence: Creative Commons: Attribution (CC-BY)

Original languageEnglish
Article number13624
JournalNature Communications
Volume8
Early online date18 Jan 2017
DOIs
Publication statusE-pub ahead of print - 18 Jan 2017

Abstract

The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer’s disease (rg¼ 0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.

Download statistics

No data available

ID: 30981193