Edinburgh Research Explorer

Novel methods for quantifying individual host response to infectious pathogens for genetic analyses

Research output: Contribution to journalArticle

Related Edinburgh Organisations

Open Access permissions



  • Download as Adobe PDF

    Rights statement: Copyright © 2012 Doeschl-Wilson, Bishop, Kyriazakis and Villanueva. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

    Final published version, 860 KB, PDF document

Original languageEnglish
Article number266
JournalFrontiers in genetics
Issue numberOctober
Publication statusPublished - 2012


Here we propose two novel approaches for describing and quantifying the response of individual hosts to pathogen challenge in terms of infection severity and impact on host performance. The first approach is a direct extension of the methodology for estimating group tolerance – the change in performance with respect to changes in pathogen burden in a host population – to the level of individuals. The second approach aims to capturethe dynamic aspects of individual resistance and tolerance over the entire time course of infections. In contrast to the first approach, which provides a means to disentangle host resistance from tolerance, the second approach considers the combined effects of host resistance and tolerance. Both approaches provide new individual phenotypes for subsequent genetic analyses and come with specific data requirements. Consideration of individual tolerance also highlights some of the assumptions hidden within the concept of group tolerance, indicating where care needs to be taken in trait definition and measurement.

Download statistics

No data available

ID: 5091732