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Novel Relationships between Porcine Fetal Size, Sex, and Endometrial Angiogenesis

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Original languageEnglish
JournalBiology of Reproduction
Early online date23 Apr 2019
Publication statusE-pub ahead of print - 23 Apr 2019
EventFertility 2018 conference - Liverpool, United Kingdom
Duration: 4 Jan 20186 Jan 2018


It is hypothesized that growth restriction occurs due to inadequate vascularization of the feto-maternal interface. Evidence exists for sexual dimorphism in placental function although associations between fetal sex and the endometrium remain poorly investigated. This study investigated the relationship between porcine fetal size, sex and endometrial angiogenesis at multiple gestational days (GD).
Endometrial samples supplying the lightest and closest to mean litter weight (CTMLW), male and female Large White X Landrace conceptuses or fetuses were obtained at GD18, 30, 45, 60 and 90 (n = 5–9 litters/GD). Immunohistochemistry for CD31 revealed a greater number of blood vessels in endometrium supplying females compared to those supplying males at GD45. Endometrial samples supplying the lightest fetuses had fewer blood vessels (GD60) and uterine glands (GD90) compared to those supplying the CTMLW fetuses. Quantitative PCR revealed decreased CD31 (GD60), HPSE and VEGFA (GD90) expression, alongside increased HIF1A (GD45) expression in endometrial samples supplying the lightest compared to the CTMLW fetuses. Endothelial cell branching assays demonstrated impaired endothelial cell branching in response to conditioned media from endometrial samples supplying the lightest and female fetuses compared with the CTMLW and male fetuses respectively.
This study has highlighted that endometrial tissues supplying the lightest and male fetuses have impaired angiogenesis. Importantly, the relationship between fetal size, sex and endometrial vascularity is dynamic and dependent upon the GD investigated

    Research areas

  • Vascularity, Intrauterine Growth Restriction (IUGR), Sexual Dimorphism, Pregnancy, Porcine, Reproduction, Fetal Growth


Fertility 2018 conference


Liverpool, United Kingdom

Event: Conference

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