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Nuclear RNA decay pathways aid rapid remodeling of gene expression in yeast

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Original languageEnglish
Pages (from-to)787–800.e5
JournalMolecular Cell
Issue number5
Publication statusPublished - 9 Feb 2017


Long-standing observations by the group indicated that the activity of nuclear RNA degradation by the exosome nuclease complex is responsive to nutrient availability. This paper revealed that alterations in nuclear surveillance contribute, both positively and negatively, to the rapid remodeling of gene expression following nutrient shift. This identified nuclear RNA surveillance as an actively regulated step in gene expression. It seems likely that changes in nuclear RNA degradation pathways will play important roles in other situations that require large scale reprogramming of gene expression, such as developmental steps in metazoans.

    Research areas

  • RNA polymerase II , RNA exosome, RNA surveillance, gene expression

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