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On the use of post-transcriptional processing elements in transgenes

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Original languageEnglish
Pages (from-to)75-9
Number of pages5
JournalTransgenic Research
Issue number1
Publication statusPublished - Feb 2004


RNA processing events modulate final productivity of a given transgene. We have evaluated a series of RNA elements for their ability to enhance alpha1-antitrypsin production in mammary cells. Our results indicate the need for a case-by-case assessment of each construct design and the occurrence of gene silencing events in vivo.

    Research areas

  • Animals, Gene Silencing, Gene Transfer Techniques, Mice, Mice, Transgenic, RNA, RNA Processing, Post-Transcriptional, Transfection, Transgenes

ID: 8778140