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Optimization and comparison of myocardial T1 techniques at 3T in patients with aortic stenosis

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    Rights statement: © The Author 2013. Published by Oxford University Press on behalf of the European Society of Cardiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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http://ehjcimaging.oxfordjournals.org/content/15/5/556
Original languageEnglish
Pages (from-to)556-565
Number of pages10
JournalEuropean Heart Journal - Cardiovascular Imaging
Volume15
Issue number5
DOIs
Publication statusPublished - May 2014

Abstract

Aims To determine the optimal T1 mapping approach to assess myocardial fibrosis at 3T.

Methods and results T1 mapping was performed at 3T using the modified look-locker-inversion sequence in 20 healthy volunteers and 20 patients with aortic stenosis (AS). Pre- and post-contrast myocardial T1, the partition coefficient (lambda; Delta R-myocardium/Delta R-blood, where Delta R = 1/post-contrast T1 - 1/pre-contrast T1), and extracellular volume fraction [ECV; lambda (1 - haematocrit)] were assessed. After establishing the optimal time point and myocardial region for analysis, we compared the reproducibility of these T1 measures and their ability to differentiate asymptomatic patients with AS from healthy volunteers. There was no segmental variation across the ventricle in any of the T1 measures evaluated. and ECV did not vary with time, while post-contrast T1 was relatively constant between 15 and 30 min. Thus, mid-cavity myocardium at 20 min was used for subsequent analyses. ECV displayed excellent intra-, inter-observer, and scanrescan reproducibility [intra-class correlation coefficients (ICC) 1.00, 0.97, and 0.96, respectively], as did lambda (ICC 0.99, 0.94, 0.93, respectively). Moreover, ECV and were both higher in patients with AS compared with controls (ECV 28.3 +/- 1.7 vs. 26.0 +/- 1.6%, P 0.05).

Conclusion ECV appears to be the most promising measure of diffuse myocardial fibrosis at 3T based upon its superior reproducibility and ability to differentiate disease from health.

    Research areas

  • diffuse myocardial fibrosis, t1 mapping, cardiac magnetic resonance imaging, aortic stenosis, CARDIOVASCULAR MAGNETIC-RESONANCE, EXTRACELLULAR VOLUME FRACTION, INTRAINDIVIDUAL ASSESSMENT, FIBROSIS, INFARCTION, CARDIOMYOPATHY, DISEASE, HEART, VALVE, ASSOCIATION

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