Edinburgh Research Explorer

Origins of fibrosis: pericytes take centre stage

Research output: Contribution to journalArticle

Related Edinburgh Organisations

Open Access permissions

Open

Documents

  • Download as Adobe PDF

    Rights statement: Copyright © 2013 Faculty of 1000 Ltd This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. You may not use this work for commercial purposes

    Final published version, 644 KB, PDF document

    Licence: Creative Commons: Attribution Non-Commercial (CC-BY-NC)

http://f1000.com/prime/reports/m/5/37
Original languageEnglish
Pages (from-to)37
JournalF1000prime reports
Volume5
DOIs
Publication statusPublished - 2 Sep 2013

Abstract

Pericytes are ubiquitous perivascular cells that have recently attracted interest as potential myofibroblast precursors. In turn, myofibroblasts are the major source of extracellular matrix components that accumulate during tissue fibrosis. Given the worldwide burden of fibrotic disease and paucity of therapeutic options available to halt its progression, elucidating the origins of myofibroblasts is of prime importance. The advent of genetic strategies that permit fate-mapping of specific cell populations through permanent and heritable expression of reporter proteins has begun to shed light on the source of the fibrogenic myofibroblast. Here we discuss recent studies in multiple organs that highlight the central role of pericytes in the origins of fibrosis.

Download statistics

No data available

ID: 10768012