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Palladium-mediated in situ synthesis of an anticancer agent

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http://xlink.rsc.org/?DOI=C6CC08666G
Original languageEnglish
Pages (from-to)14212-14214
JournalChemical Communications
Volume52
Issue number99
Early online date25 Nov 2016
DOIs
Publication statusE-pub ahead of print - 25 Nov 2016

Abstract

As a novel prodrug activation strategy Pd(0) nanoparticles, entrapped within a modular polymeric support, were used in cell culture, to synthesise the anticancer agent PP-121 from two non-toxic precursors, thereby inducing cell death in the first example of in situ mediated drug synthesis.

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