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Palladium-mediated intracellular chemistry

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http://www.nature.com/nchem/journal/v3/n3/full/nchem.981.html#/affil-auth
Original languageEnglish
Pages (from-to)239-243
Number of pages5
JournalNature Chemistry
Volume3
Issue number3
DOIs
Publication statusPublished - Mar 2011

Abstract

Many important intracellular biochemical reactions are modulated by transition metals, typically in the form of metalloproteins. The ability to carry out selective transformations inside a cell would allow researchers to manipulate or interrogate innumerable biological processes. Here, we show that palladium nanoparticles trapped within polystyrene microspheres can enter cells and mediate a variety of Pd-0-catalysed reactions, such as allylcarbamate cleavage and Suzuki-Miyaura cross-coupling. The work provides the basis for the customization of heterogeneous unnatural catalysts as tools to carry out artificial chemistries within cells. Such in cellulo synthesis has potential for a plethora of applications ranging from cellular labelling to synthesis of modulators or inhibitors of cell function.

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