Edinburgh Research Explorer

Pathogenesis of biomaterial-associated infection

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Original languageEnglish
Title of host publicationRacing for the Surface: Pathogenesis of Implant Infection and Advanced Antimicrobial Strategies
PublisherSpringer
Publication statusPublished - Mar 2020

Abstract

Biomaterial infections associated with indwelling surgical devices are responsible for ~50% of all nosocomial infections. The development of orthopaedic biomaterial-associated infections comes at great physical and emotional cost to patients, resulting in substantial economic costs to health-providers. Understanding of its pathogenesis has progressed greatly since the biofilm hypothesis was first proposed. However, the biofilm hypothesis only partially elucidates the pathogenesis of these infections. A greater appreciation of the mechanisms underpinning immune evasion by common pathogens has highlighted a previous underestimation of the role this behaviour has in the development of these troublesome infections. Recognition of the importance of the immune system interaction in the pathogenesis of biomaterial-associated infections will not only update our paradigm of this condition but will also help to identify and develop potential therapeutic targets. This review aims to provide an overview of the pathogenesis of biomaterial-associated infections. It focuses primarily on the development of bacterial biofilms and the immune-evasive behaviour of the most common orthopaedic pathogens.

ID: 105260941