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Pedigree- and SNP-Associated Genetics and Recent Environment are the Major Contributors to Anthropometric and Cardiometabolic Trait Variation

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    Rights statement: Copyright: © 2016 Xia et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1005804
Original languageEnglish
Article numbere1005804
JournalPLoS Genetics
Volume12
Issue number2
DOIs
StatePublished - 2 Feb 2016

Abstract

Unravelling overall trait architecture of complex traits and diseases is important for phenotype prediction and disease prevention and correct modelling of the trait will further aid discovery of causative loci. Here we take advantage of genome-wide data and a large family-based study to examine the role of common genetic variants, pedigree-associated genetic variants, shared family environment, shared couple environment and shared sibling environment on 16 anthropometric and cardiometabolic traits. By analysing up to ~20,000 Scottish individuals, we find that common genetic variants, pedigree-associated genetic variants and recently-shared environment of couples are the most important contributors to variation in these traits, while past family and sibling environment have a limited impact. Further studies on the pedigree-associated genetic variation and the shared couple environment effect are needed, as little research has been devoted to them so far.

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