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Personality, Health, and Brain Integrity: The Lothian Birth Cohort Study 1936

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    Rights statement: © Personality, Health, and Brain Integrity : The Lothian Birth Cohort Study 1936. / Booth, Tom; Mõttus, Rene; Corley, Janie; Gow, Alan J; Henderson, Ross D; Munoz-Maniega, Susana; Murray, Catherine; Royle, Natalie A; Sprooten, Emma; Hernández, Maria C Valdés; Bastin, Mark E; Penke, Lars; Starr, John M; Wardlaw, Joanna M; Deary, Ian J. In: Health Psychology, 2013. Research output: Contribution to journal › Article

    Accepted author manuscript, 1.47 MB, PDF document

Original languageEnglish
Pages (from-to)1477-1486
Number of pages10
JournalHealth Psychology
Issue number12
Early online date18 Nov 2013
Publication statusPublished - Dec 2014


Objective: To explore associations between the 5-factor model (FFM; neuroticism, extraversion, openness/intellect, agreeableness, and conscientiousness), personality traits, and measures of whole-brain integrity in a large sample of older people, and to test whether these associations are mediated by health-related behaviors. Method: Participants from the Lothian Birth Cohort 1936 completed the International Personality Item Pool measure, a 5-factor public-domain personality measure (http://ipip.ori.org), and underwent a structural magnetic resonance brain scan at the mean age of 73 years, yielding 3 measures of whole brain integrity: average white matter fractional anisotropy (FA), brain-tissue loss, and white matter hyperintensities (N = 529 to 565). Correlational and mediation analyses were used to test the potential mediating effects of health-related behaviors on the associations between personality and integrity. Results: Lower conscientiousness was consistently associated with brain-tissue loss (β = -0.11, p

    Research areas

  • five-factor model, brain volume, white matter hyperintensities, fractional anisotropy, health behaviors, BODY-MASS INDEX, WHITE-MATTER INTEGRITY, 6-YEAR FOLLOW-UP, ALZHEIMERS-DISEASE, PHYSICAL-ACTIVITY, OLDER-ADULTS, AGE, TRAITS, SAMPLE, VOLUME

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