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Placental Hormone Profiles As Predictors Of Preterm Birth In Twin Pregnancy: A Prospective Cohort Study

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    Rights statement: rticle Source: Placental hormone profiles as predictors of preterm birth in twin pregnancy: A prospective cohort study Lim H, Powell S, Mcnamara HC, Howie AF, Doust A, et al. (2017) Placental hormone profiles as predictors of preterm birth in twin pregnancy: A prospective cohort study. PLOS ONE 12(3): e0173732. doi: 10.1371/journal.pone.0173732

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Original languageEnglish
Article numbere0173732
JournalPLoS ONE
Volume12
Issue number3
DOIs
Publication statusPublished - 9 Mar 2017

Abstract

Objective The objective of the study was to analyse placental hormone profiles in twin pregnancies to determine if they could be used to predict preterm birth. Study design Progesterone, estradiol, estriol and corticotropin-releasing hormone were measured using competitive immunoassay and radioimmunoassay in serum and saliva samples of 98 women with twin pregnancies,at 3 or more gestational timepoints. Hormone profiles throughout gestation were compared between very preterm (<34 weeks; n = 8), preterm (<37 weeks; n = 40) and term (37+ weeks; n = 50) deliveries. Results No significant differences were found between preterm and term deliveries in either absolute hormone concentrations or ratios. Estimated hormone concentrations and ratios at 26 weeks did not appear to predict preterm delivery. Salivary and serum hormone concentrations were generally poorly correlated. Conclusion Our results suggest that serial progesterone, estradiol, estriol and corticotropin-releasing hormone measurements in saliva and serum are not robust biomarkers for preterm birth in twin pregnancies.

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