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Plant Polycomb-Group Proteins: Epigenetic regulators of development

Research output: Contribution to journalArticle

Original languageEnglish
Article number10.1002/9780470015902.a0023751
Pages (from-to)1-12
Number of pages12
StatePublished - 15 Sep 2016


Although all cells in a multicellular organism
contain the same set of genes, the spatiotemporal
expression of these genes needs to be
dynamically regulated for proper development
(i.e. morphogenesis and life cycle transitions) to
take place. Epigenetic mechanisms (i.e. heritable
but reversible changes to chromatin) are important
to maintain such gene expression patterns.
Polycomb-group proteins are evolutionarily conserved
epigenetic regulators that function – via
epigenetic marks such as histone modifications
and alterations to chromatin structure – to maintain
the repression of developmentally important
genes so that these genes are expressed appropriately.
Although they maintain specific patterns
of gene repression, Polycomb-group proteins are
ubiquitously expressed. How their activity is regulated
is a largely unexplored area but recent
research in both metazoans and plants suggests
myriad methods of regulation, including control
of RNA (ribonucleic acid) and protein abundance
and stability, post-translational modifications
and interactions with proteins and noncoding

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