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Polymeric glabrescione B nanocapsules for passive targeting of Hedgehog-dependent tumor therapy in vitro

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  • Cinzia Ingallina
  • Pedro M Costa
  • Francesca Ghirga
  • Rebecca Klippstein
  • Julie T Wang
  • Simone Berardozzi
  • Naomi Hodgins
  • Paola Infante
  • Steven M Pollard
  • Bruno Botta
  • Khuloud T Al-Jamal

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    Rights statement: This article is distributed under the terms of the Creative Commons Attribution License 4.0 which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. To view a copy of the license, visit http://creativecommons.org/licenses/by/4.0/

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Original languageEnglish
Pages (from-to)711-728
Number of pages18
JournalNanomedicine
Volume12
Issue number7
Early online date21 Mar 2017
DOIs
Publication statusPublished - Apr 2017

Abstract

AIM: With the purpose of delivering high doses of glabrescione B (GlaB) to solid tumors after systemic administration, long-circulating GlaB-loaded oil-cored polymeric nanocapsules (NC-GlaB) were formulated.

MATERIALS & METHODS: Synthesis of GlaB and its encapsulation in nanocapsules (NCs) was performed. Empty and GlaB-loaded NCs were assessed for their physico-chemical properties, in vitro cytotoxicity and in vivo biodistribution.

RESULTS: GlaB was efficiently loaded into NCs (∽90%), which were small (∽160 nm), homogeneous and stable upon storage. Further, GlaB and NC-GlaB demonstrated specific activities against the cancer stem cells. Preliminary studies in tumor-bearing mice supported the ability of NC to accumulate in pancreatic tumors.

CONCLUSION: This study provides early evidence that NC-GlaB has the potential to be utilized in a preclinical setting and justifies the need to perform therapeutic experiments in mice.

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