Edinburgh Research Explorer

Polymorphisms in the endothelin-1 (EDN1) are associated with asthma in two populations

Research output: Contribution to journalArticlepeer-review

  • G. Zhu
  • K. Carlsen
  • K-H Carlsen
  • W. Lenney
  • M. Silverman
  • M. K. Whyte
  • L. Hosking
  • P. Helms
  • A. D. Roses
  • D. W. Hay
  • M. R. Barnes
  • W. H. Anderson
  • S. G. Pillai

Related Edinburgh Organisations

Original languageEnglish
Pages (from-to)23-29
Number of pages7
JournalGenes and Immunity
Volume9
Issue number1
DOIs
Publication statusPublished - Jan 2008

Abstract

Endothelin-1 (EDN1) has been reported to be implicated in the pathophysiology of asthma. Literature results on the genetic association of EDN1 in asthma are inconsistent. Eleven single nucleotide polymorphisms in EDN1 were genotyped in 342 and 100 families from UK and Norway, respectively. Asthma, bronchial hyperreactivity (BHR) and atopic asthma phenotypes were analyzed for the family-based association. Five single nucleotide polymorphisms (SNPs) were associated with asthma (0.0017

    Research areas

  • asthma, EDN1, genetic association, haplotype analysis, replication, GENOME-WIDE SEARCH, BRONCHOALVEOLAR LAVAGE FLUID, CHROMOSOMAL ASSIGNMENT, SUSCEPTIBILITY LOCI, FOUNDER POPULATION, GENE POLYMORPHISMS, ATOPIC DISEASES, CANDIDATE GENES, RECEPTOR, FAMILY

ID: 17208697