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Polymorphisms in the gene encoding 11B-hydroxysteroid dehydrogenase type 1 (HSD 11B1) and lifetime cognitive change

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)74-77
Number of pages4
JournalNeuroscience Letters
Volume393
Issue number1
DOIs
Publication statusPublished - 23 Jan 2006

Abstract

A rare polymorphism in the gene encoding 11B-hydroxysteroid dehydrogenase type 1 (HSD11B1: rs846911-C/A) has been associated with an increased risk of Alzheimer's disease. We tested the hypothesis that this and 2 other HSD11B1 polymorphisms (rs 12086634-G/T and rs846910-A/G) were associated with lifetime cognitive change in humans. Subjects were 194 participants of the Scottish Mental Survey of 1932 who took the same well-validated mental test at age 11 and age 79. The subjects represented the highest and lowest quintiles with respect to cognitive decline between ages 11 and 79. Despite having non-significantly different IQs at age 11, by age 79 the groups had mean (S.D.) IQs of 80.3 (14.1) and 109.6 (9.1), respectively (p < .001). The polymorphism rs846911-C/A was absent from both groups. There were no significant differences in the frequency of polymorphisms of rs12086634-G/T (p = .91) and rs846910-A/G (p = .90) between the groups. We conclude that these variants in HSD11B1 are not significant contributors to the range of cognitive ageing examined here. (C) 2005 Elsevier Ireland Ltd. All rights reserved.

    Research areas

  • 11B-hydroxysteroid dehydrogenase type 1, HSD11B1, cognitive ageing, IQ, verbal reasoning, PITUITARY-ADRENAL ACTIVITY, 11-BETA-HYDROXYSTEROID DEHYDROGENASE, GLUCOCORTICOID ACTION, PIMA-INDIANS, HIPPOCAMPUS, IMPAIRMENTS, METABOLISM, EXPRESSION, CORTISOL, MEMORY

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