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Posterior cingulate neurometabolite profiles and clinical phenotype in frontotemporal dementia

Research output: Contribution to journalArticlepeer-review

  • Peter Garrard
  • Jonathan M Schott
  • David G MacManus
  • John R Hodges
  • Nicholas C Fox
  • Adam D Waldman

Related Edinburgh Organisations

Original languageEnglish
Pages (from-to)185-9
Number of pages5
JournalCognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology
Issue number4
Publication statusPublished - Dec 2006


Proton magnetic resonance spectroscopy was used to compare metabolite levels from a posterior cingulate voxel in a group of patients with 2 syndromic subtypes of frontotemporal dementia (n=10) and an age and education-matched group with Alzheimer disease (n=10). Overall, frontotemporal dementia was indistinguishable from Alzheimer disease, though differences in N-acetylaspartate emerged between patients with the SD and progressive nonfluent aphasia subtypes, attributable to 2 atypical results among the latter. Such values may index cases with atrophy in posterior cortical regions presenting with progressive nonfluent aphasia.

    Research areas

  • Aged, Alzheimer Disease, Aspartic Acid, Atrophy, Dementia, Diagnosis, Differential, Female, Frontal Lobe, Humans, Inositol, Magnetic Resonance Spectroscopy, Male, Matched-Pair Analysis, Middle Aged, Temporal Lobe, Comparative Study, Journal Article

ID: 46190907