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Prevalence and sequence diversity of a factor required for actin-based motility in natural populations of Burkholderia species

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    Rights statement: Copyright © 2008, American Society for Microbiology

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Original languageEnglish
Pages (from-to)2418-2422
Number of pages5
JournalJournal of Clinical Microbiology
Issue number7
Publication statusPublished - Jul 2008


Actin-based motility of the melioidosis pathogen Burkholderia pseudomallei requires BimA. We report a high degree of conservation of bimA in 99 B. pseudomallei isolates from the area of endemicity. A geographically restricted subset of B. pseudomallei isolates harbored a B. mallei-like bimA allele (12.1%), confounding a differential diagnostic test based on amplification of species-specific bimA regions.

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