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Probabilistic inference of synaptic dynamics in neocortical microcircuits

Research output: Contribution to conferencePosterpeer-review

Original languageEnglish
Publication statusPublished - Jul 2013
Event22nd Annual Computational Neuroscience Meeting: CNS 2013 - Université Paris Descartes, 45 rue des Saints-Pères, Paris, France
Duration: 13 Jul 201318 Jul 2013


Conference22nd Annual Computational Neuroscience Meeting: CNS 2013


Short-term synaptic plasticity (STP) is highly varied across brain area, cortical layer, cell type, and developmental stage (Reyes & Sakmann 1999). This variability is probably not coincidental and since synaptic dynamics shape neural computations, it suggests an important role of STP in neural information processing (Abbott & Regehr 2004). Therefore, an accurate description of STP is a key step towards a comprehensive understanding of neural systems. Many phenomenological STP models have been developed (Markram et al. 1998), but they have typically been fitted to experimental data using least-mean-square methods. With the Tsodyks-Markram model, we find that for typical synaptic dynamics such fitting procedures may give erratic outcomes. A Bayesian formulation based on a Markov Chain Monte Carlo method was introduced as a solution. This formulation provides the posterior distribution over the model parameters given the data statistics. We discovered that standard STP electrophysiology protocols yielded wide distributions over some model parameters. Based on this result we propose experimental protocols to more accurately determine model parameters. Next, the model parameters were inferred using experimental data from three different neocortical excitatory connection types: Pyramidal Cell-Pyramidal Cell (PC-PC), Pyramidal Cell-Basket Cell (PC-BC) and Pyramidal Cell-Martinotti Cell (PC-MC), (see Figure 1). This disclosed connection-specific distributions, which we used to classify synapses. This approach to determining connection-specific synaptic dynamics provides a more comprehensive representation of STP and unveils novel features from existing data.


22nd Annual Computational Neuroscience Meeting: CNS 2013


Paris, France

Event: Conference

ID: 14721625