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Producing recombinant human milk proteins in the milk of livestock species

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Original languageUndefined/Unknown
Title of host publicationBioactive components of milk
EditorsB. Bosze
PublisherSpringer-Verlag GmbH
Pages357-395
Number of pages39
Publication statusPublished - 2008

Publication series

NameAdvances in Experimental Medicine and Biology
PublisherBerlin: Springer

Abstract

Recombinant human proteins produced by the mammary glands of genetically modified transgenic livestock mammals represent a special aspect of milk bioactive components. For therapeutic applications, the often complex posttranslational modifications of human proteins should be recapitulated in the recombinant products. Compared to alternative production methods, mammary gland production is a viable option, underlined by a number of transgenic livestock animal models producing abundant biologically active foreign proteins in their milk. Recombinant proteins isolated from milk have reached different phases of clinical trials, with the first marketing approval for human therapeutic applications from the EMEA achieved in 2006

    Research areas

  • animal biotechnology Mammary pharmaceutical recombinant proteins

ID: 271201